Datasets I Wish I Had

There are a surprisingly large number of situations in which we don't have much data at all, so I keep a running list of datasets I wish I had for things I'm curious about. Updated irregularly.

Human Health
  • Longitudinal datasets on all diseases with states that evolve over time: cancer, COPD, joint damage, NASH, etc including treatment annotations
  • Andropause
  • Salutogenic datasets: wound healing and stroke recovery trajectories
  • Spatial map of microbiome communities along length of intestine instead of descending colon snapshots
  • Mucosal barrier tissue-resident immune memory profiling to repeated exposure to similar antigens
  • Hematopoiesis alterations in clusters of co-morbid conditions
  • Autoantibody repertoires throughout life and correlates with changes in antigen expression in medullary thymic epithelial cells
  • Endocrine changes after deliberate induction of ketogenic or fasted states
  • Hypothalamal stem cell activity after hormetic insults, including exosome profiling
  • Exocrine cell type functional and regulatory profiling under various stressor conditions (e.g., goblet cells in GERD)
  • Limits on cell stress responses in various cell types: how close can they come to apoptotic shutdown but still recover? What signaling or metabolic substrates modify recoverability speed or penetrance?
Ecology
  • Lichen proteomics and epigenetic changes through dry to wet season transitions for variety of species
  • Mucin atlas and dehydration profiling
  • Hair follicle shifts when a dog blows its coat for the season
  • Mycelium contact tracing dyes
  • Moss stress responses to dehydration and sequence of rapid recovery on rehydration
Bioproduction
  • Longitudinal metabolic utilization in model organisms optimized for large scale production (K12 E. Coli, yeast, hybridomas)
  • Mucin atlas and dehydration profiling
  • Reverse genetics on IFNAR/CXCR/ILRs in cell therapy production donors
  • Stress resolution after electroporation or other transfection protocol
  • Missing technology: Golgi post-translational modification editing engineering